Mucosal architecture:
Mucosal surface, normal, irregular, villous
Crypt atrophy (shortened, widely spaced crypts)
Distorted, dilated, branching crypts
Inflammatory changes:
Basal plasmacytosis, increase in cells in basal third of lamina
propria
Increased lamina propria cellularity (round cells and
neutrophils)
Basal lymphoid aggregates
Specific features:
Epithelioid granuloma
Basal giant cells
Excess histiocytes in lamina propria
Features related with activity (separating IBD from normal):
Neutrophils in surface epithelium
Neutrophils in crypt epithelium
Ulceration
UC:
Architecture:
Severe crypt architectural distortion
Severe widespread decreased crypt density
Frankly villous surface
Inflammatory:
Heavy diffuse transmucosal lamina propria cell increase
Diffuse basal plasmacytosis
Miscellaneous:
Increased intensity of the alterations towards the distal colon
Severe mucin depletion
Paneth-cell metaplasia distal to the hepatic flexure
A 19-year-old student presents with weight loss and blood loss per rectum. You organise a flexible sigmoidoscopy.
ReplyDeleteWhich of the following histological features would favour a diagnosis of Crohn's disease and not ulcerative colitis?
1-Caseating granulomata
2-Crypt abscesses
3-Goblet cell mucus depletion
4-Lymphocyte infiltrate of the lamina propria
5-Metaplastic polyp formation
Ulcerative colitis is characterised by mucosal inflammation with
General inflammatory cell infiltration
Goblet-cell mucus depletion
Crypt abscesses
Crypt shortening
Branching.
There is continuous inflammation, worsening from caecum to rectum.
In contrast, Crohn's disease is characterised by transmural inflammation, with
Lymphocytic infiltrates and lymphoid aggregates
Fissures
Preservation of crypt architecture
Non-caseating granulomata.
There is patchy inflammation from mouth to anus.
monzygos twn studies shaw high concordance for CD 70%, but less so for UC. 1st gegree relatvie has 5-20% increase fold risk of developing IBD. the child of parents with IBD have 5% risk of developing IBD.
ReplyDeleteenviormental factors: smoking and appendectomy reduce risk of UC, smoking increase risk of CD.
ReplyDeleteDr Itua cure my HIV, I have been a ARV Consumption for 10 years. i have been in pains until i came across Dr Itua on blogs site.I emailed him about my details of my HIV and my location i explained every thing to him and he told me that there is nothing to be scared of that he will cured me, he gave me guarantee,He ask me to pay for items fees so when i'm cured I will show gratitude I did and giving testimony of his healing herbs is what I'm going to do for the rest of you out there having HIV and other disease can see the good work of Dr Itua.I received his herbal medicine through EMS Courier service who delivered to my post office within 5 working days.Dr Itua is an honest man and I appreciate him for his good work.My GrandMa called him to appreciate him and rest of my friends did too,Is a joy to me that I'm free of taking Pills and having that fat belle is a nightmare.you will understand what i'm talking about if you have same problem I was having then not now though.I'm free and healthy Big Thanks To Dr Itua Herbal Center.I have his calendar too that he recently sent me,He Cure all kind disease Like,Cancer,Weak Erection,Wart Remover,Hpv,Herpes,Alzheimer’s disease,Bechet’s disease,Crohn’s disease,Cushing’s disease,Heart failure,Multiple Sclerosis,Hypertension,Fibromyalgia,Hiv,Hepatitis B,Liver/Kidney Inflamatory,Epilepsy,Blood Cancer,Prostate Cancer,Colo-Rectal Cancer,Brain Cancer,Lung Cancer,Infertility,Parkinson's disease,Schizophrenia,Lung Cancer,Breast Cancer,Colo-Rectal Cancer,Blood Cancer,Prostate Cancer,siva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,measles, tetanus, whooping cough, tuberculosis, polio and diphtheriaAmyotrophic Lateral Scoliosis,Fibromyalgia,Fluoroquinolone ToxicitySyndrome Fibrodysplasia Ossificans ProgresSclerosis,Seizures,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpe ,Copd,Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,
ReplyDeleteDementia.Fibroid,Diabetes,Dercum,Copd ,and also Bring back Ex Lover Back..Here his Contact .drituaherbalcenter@gmail.com Or Whats_app Number +2348149277967
My sister was diagnosed of Creutzfeldt–Jakob disease (CJD) in early last year , our doctor told us there is no permanent cure for the CJD condition, she was given medications to slow down the progress of the disease, at the initial stage it was not so bad till it progressed to the end stage were she had difficulties going about her daily functions as she constantly had difficulty speaking,mental confusion,blurred vision include, we were all totally devastated not until my daughter’s co-worker told us about a herbal formula from totalcureherbsfoundation .com which has the right herbal formula for my sister Creutzfeldt–Jakob disease , when I contact this herbal foundation through their email totalcureherbalfoundation@ gmail. com I wasn’t certain the herbal treatment will get rid of herbal disease not until she complete the treatment as instructed, she will be resuming her work next month because this herbal cure seriously reverse her condition which we never expected ,im referring this to anybody at there suffering from this condition and they have assurance about this treatments
ReplyDeleteI was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
ReplyDeleteliver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.
Hey there, very informative blog. I am also seeing an incredible gastro doctor in Ludhiana at Girn Hospital. Their treatment has been very effective for me.
ReplyDeleteLife-Changing Experience with Dr. Marcus Schmitz, Neurosurgeon Extraordinaire
ReplyDeleteDear All,
I am writing to share my profound appreciation for Dr. Marcus Schmitz, a distinguished neurosurgeon who has been instrumental in curing my daughter's epileptic disease. For 13 long years, we battled this condition, but it was Dr. Schmitz's unique approach using natural remedies and treatments that finally brought us relief. 🙏
His expertise extends beyond epilepsy, encompassing other neurological diseases like Alzheimer's, Parkinson's, and stroke. I am confident that his innovative methods can bring hope and healing to others facing similar challenges. 🧠
I urge anyone dealing with these conditions to reach out to Dr. Schmitz directly. He can be contacted via email at dr.marcusschmitz@gmail.com or through WhatsApp at +1 (973) 506‑8186. Time is of the essence in these matters, so please, do not hesitate. 🕰️
In Dr. Schmitz, you will find not just a doctor, but a dedicated ally in your fight against neurological diseases. Let's spread the word about this remarkable professional and help others find the relief they so desperately seek. 🌐
With utmost sincerity,
[scott Budde]