A middle-aged woman presents with recent changes in her bowel habits. She is investigated as a case of sporadic colonic carcinoma.
What is the mechanism of its tumorogenesis?
1- APC gene mutation
2-beta catenin suppresion
3-down regulation of p27
4-K-ras suppression
5-p53 upregulation
The cyclin-dependent kinase inhibitor p27 is a negative regulator of the cell cycle and a potential tumour suppressor gene. Its down-regulation is associated with occurrence of sporadic colon cancer.
ReplyDeleteß-catenin accumulation, not suppression, initiates adenoma formation.
p53 is a tumour suppressor gene.
Activation of K-ras oncogene is seen in sporadic colon cancer.