Curriculum for Specialty Certificate Examination in Gastroenterology

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Saturday 8 February 2014

Interstitial cells of Cajal (ICC)

Interstitial cells of Cajal (ICC) are the pacemaker cells in the intestine.
They are mesenchymal cells located in the mesentric pluxes, the muscularis properia and the submucosa throughout the small intestine and colon.
They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal muscles. 
They regulate intestinal motility through generation of slow waves and determine the frequency of contraction.
They amplify neuronal signals, mediate neurotransmission from enteric motor neurons to smooth muscles cells, and set the smooth muscles membranes potential gradient.

Gastric myoelectrical slow wave activity produced by pacemaker cells (ICC) can be reflected by electrogastrography (EGG). 

 Which of the following statements regarding interstitial cells of Cajal (ICC) is false?
  A.   They originate from c-kit–positive mesenchymal cells.
  B.   Myenteric ICC are responsible for spontaneous generation of slow waves.
  C.   Intramuscular ICC facilitate propagation of slow waves in the stomach.
  D.   Intramuscular ICC in the cardia have a role in mechanoreception.
  E.   Loss of ICC in the antrum is associated with gastroparesis.


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6 comments:

  1. Anonymous8 February 2014 at 12:52

    correct answer D
    myentric ICC generate slow waves
    inramuscular ICC propagate slow waves
    intrmuscular ICC in the funds play a role in mechanoreception.
    Loss of ICC in the antrum is associated with gastroparesis in patient with DM

    ReplyDelete
  2. Anonymous8 February 2014 at 13:25

    Hyperglycemia is associated with all of the following except:
    A. Antral hypermotility
    B. Isolated pyloric contractions
    C. Gastric dysrhythmias
    D. Impaired action of prokinetic drugs
    A
    Hyperglycemia is associated with loss of ICC, antral hypomotility, isolated pyloric contractions, gastric dysrhythmias, and impaired prokinetic action of drugs like erythromycin.

    ReplyDelete
  3. Anonymous26 February 2014 at 15:22

    the smooth muscles within each muscle layer of the samll intestine form a synctium. Their activity is locally coordinated by which of the following:
    1-ICC
    2-Enteric nervous system
    3-intrinsic neurons
    4-myentric plexus
    5-extrisic neurons

    ReplyDelete
  4. Anonymous26 February 2014 at 15:35

    with regard to the ICCs, which of the following is accurate?
    1-the distribution of these cells changes from infancy to adulthood
    2-These cells are present only in the small intestine
    3-They regulate intestinal motility by generating slow waves and the frequency of contraction
    4-Their number is regulated by dopamine

    ReplyDelete
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