NICE classification

(NICE)  the NBI international colorectal endoscopic (NICE) classification:

This classification is applicable to colorectal tumors closely observed without magnification.

It classifies colorectal tumors into:

types 1: 

Color: Same or lighter than background

Vascular pattern: None, or isolated lacy vessels may be present coursing across the lesionSurface Pattern: Dark or white spots of uniform size, or homogenous absence of pattern

e.g hyperplastic polyps.

types 2: 

Color: Browner relative to background (verify color arises from vessels)

Vascular pattern: Thick brown vessels surrounding white structures

Surface Pattern: Oval, tubular or branched white structures surrounded by brown vessels

is observed in various histopathological types such as adenoma, intramucosal cancer, and less invasive submucosal cancer.

types 3: 

Color: Brown to dark brown relative to background; sometimes patchy whiter areas

Vascular pattern: Has area(s) with markedly distorted or missing vessels

Surface Pattern:  Areas of distortion or absence of pattern

massively invasive submucosal cancer.